pde4 inhibitor — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T10028	PDE4 inhibitor intermediate 1		Others
	PDE4 inhibitor intermediate 1 is a PDE4 inhibitor synthesis intermediate.		Others
T27172	Difamilast		PDE
	Difamilast is an inhibitor of phosphodiesterase IV.		PDE
T7954	YM976		PDE
	YM976 is an orally active PDE4 inhibitor (IC50:2.2 nM)		PDE
T25376	Ensifentrine	Ensifentrina,Ensifentrinum	PDE
	Ensifentrine (Ensifentrinum) is a PDE3/4 inhibitor, although its affinity for PDE3(IC50: 0.4 nM) is 3,440 times higher than that for PDE4(IC50: 1479 nM), that is under clinical development for the treatment of asthma and...		PDE
T27475	GSK356278	GSK-356278,GSK 356278	PDE
	GSK356278 is an effective and selective inhibitor of phosphodiesterase 4 (PDE4), with pIC50s of 8.6, 8.8, and 8.7 for human PDE4A, PDE4B, and PDE4D, respectively. GSK356278 has anti-inflammatory, anxiolytic, and cognitio...		PDE
T39341	FCPR03		PDE
	FCPR03 is a selective inhibitor of phosphodiesterase 4 (PDE4) with IC50s of 31 nM, 47 nM, and 60 nM for PDE4B1, PDE4D7, and PDE4 catalytic domain, respectively. FCPR03 has neuroprotective, anti-inflammatory, and antidepr...		PDE
T6445	Cilomilast	SB-207499,Ariflo	PDE
	Cilomilast (SB-207499) is a potent PDE4 inhibitor with IC50 of about 110 nM, has anti-inflammatory activity and low central nervous system activity. Phase 3.		PDE
T6427	Butein	2’,3,4,4’-tetrahydroxy Chalcone	Apoptosis , EGFR , Others , PDE , Autophagy
	Butein (2’,3,4,4’-tetrahydroxy Chalcone), a plant polyphenol, is isolated from Rhus verniciflua. It can inhibit the activation of protein tyrosine kinase, NF-κB and STAT3, and also can inhibit EGFR.		Apoptosis , EGFR , Others , PDE , Autophagy
T5S2059	Glaucine		Calcium Channel , Dopamine Receptor , Influenza Virus , Adrenergic Receptor , PDE
	Glaucine has antitussive, antioxidative potential and antiviral activities, it may be an anti-arthritic agent, it can enhance LPS and zymosan-induced IL-10 production. Glaucine can inhibit the migration and invasion of h...
T33422	MK-0873	MK 0873,MK0873	PDE
	MK-0873 is a novel and potent selective phosphodiesterase 4 (PDE4) inhibitor.		PDE
T13448	(R)-(-)-Rolipram	(R)-Rolipram,(-)-Rolipram	DNA-PK , Others
	(R)-(-)-Rolipram ((-)-Rolipram) is an R-enantiomer of Rolipram which is a PDE4 inhibitor.		DNA-PK , Others
T9816	Arofylline	LAS 31025	PDE
	Arofylline (LAS 31025) is a PDE4 inhibitor and can be used for asthma studies.		PDE
T10316	AN3199		Others , PDE
	AN3199 is a selective inhibitor of PDE4 with an IC50 of 94.5 nM.		Others , PDE
T19865	GEBR-7b	3-(Cyclopentyloxy)-4-methoxybenzaldehyde	PDE
	GEBR-7b (3-(Cyclopentyloxy)-4-methoxybenzaldehyde) is a phosphodiesterase-4 (PDE4) inhibitor.		PDE
T34387	Ronomilast	ELB353,ELB 353,ELB-353,Elbimilast
	Ronomilast(Elbimilast, ELB 353) is a PDE4 inhibitor for chronic inflammatory disease. Ronomilast is developed to treat chronic obstructive pulmonary disease (COPD).
T27632	Isomazole		PDE
	Isomazole is a novel orally available phosphodiesterase (PDE) inhibitor with calcium-sensitizing properties that inhibits PDE3 and PDE4.		PDE
T5101	BW-A 78U	BW-A78U	PDE
	BW-A 78U is a PDE4 inhibitor (IC50: 3 μM). It is not inhibition on the lipopolysaccharide (LPS)-induced TNF-α release.		PDE
T22851	ICI 63197	2-Amino-6-methyl-4-propyl-[1,2,4]triazolo[1,5-a]pyrimidin-5(4H)-one	PDE
	ICI 63197 (2-Amino-6-methyl-4-propyl-[1,2,4]triazolo[1,5-a]pyrimidin-5(4H)-one) is a PDE4 inhibitor.		PDE
T28991	Tofimilast	CP-325,366,CP-325366,CP325366,CP 325,366,CP 325366	PDE
	Tofimilast (CP-325366), a PDE4 inhibitor, is used potentially for the treatment of asthma and chronic obstructive pulmonary disease.		PDE
T23154	Piclamilast	RPR 73401,RP 73401	PDE
	Piclamilast (RP 73401) is a PDE4 inhibitor.		PDE